2. Gene
  3. Nfasc - neurofascin Gene

Nfasc - neurofascin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NF

Gene ID: 116690 | Gene type: protein coding

About Nfasc

Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular Cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Nfasc Products(4)

mRNA Protein Name
NM_001160313.2 NP_001153785.2 neurofascin isoform 2 precursor
NM_001160314.2 NP_001153786.1 neurofascin isoform 1 precursor
NM_001160315.2 NP_001153787.1 neurofascin isoform 4 precursor
NM_053909.3 NP_446361.2 neurofascin isoform 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11470829 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17045809 RGD
Biological Process GO Annotation Evidence Reference Source
involved in myelination IEP
IEP: Inferred from expression pattern
16652168 RGD
involved in peripheral nervous system development IEP
IEP: Inferred from expression pattern
16652168 RGD
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
16525039 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Schwann cell microvillus IDA
IDA: Inferred from direct assay
17045809 RGD
located in axon IDA
IDA: Inferred from direct assay
22649224 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
11724816 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22649224 RGD
located in node of Ranvier IDA
IDA: Inferred from direct assay
11470829 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11470829 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofascin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09236 NFASC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20065 Nfasc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26569 Nfasc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfasc NCBI NCBI:23114