2. Gene
  3. Timp1 - TIMP metallopeptidase inhibitor 1 Gene

Timp1 - TIMP metallopeptidase inhibitor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Timp; TIMP-1

Gene ID: 116510 | Gene type: protein coding

About Timp1

Summary

Enables protease binding activity. Involved in several processes, including cartilage development; response to peptide hormone; and wound healing. Located in basement membrane. Used to study degenerative disc disease. Biomarker of cholestasis; gastric ulcer; heart disease (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Timp1 Products(1)

mRNA Protein Name
NM_053819.1 NP_446271.1 metalloproteinase inhibitor 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protease binding IPI
IPI: Inferred from physical interaction
21846328 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
28659595 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cartilage development IEP
IEP: Inferred from expression pattern
16208432 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
17555880 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12081564 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
10435007 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
1327205 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
9579471 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 1

tissue inhibitor of metallopeptidase 1

tissue inhibitor of metalloproteinase 1

tissue inhibitor of metalloproteinases 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-154919 DC-Y13-27 99.52% Unkown
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-151932 FXR agonist 3 Agonist 95.94% Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-RS14538 TIMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162902 ALK5-IN-82 Inhibitor / Unkown
HY-RS16840 Timp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23282 Timp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp1 NCBI NCBI:7076
Mus musculus Timp1 NCBI NCBI:21857