Adnp - activity-dependent neuroprotective protein Gene

Mus musculus

Also known as mKIAA0784

Gene ID: 11538 | Gene type: protein coding

About Adnp

Summary

This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and Autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Adnp Products(3)

mRNA	Protein	Name
NM_001310086.1	NP_001297015.1	activity-dependent neuroprotector homeobox protein isoform 1
NM_001310088.1	NP_001297017.1	activity-dependent neuroprotector homeobox protein isoform 2
NM_009628.3	NP_033758.2	activity-dependent neuroprotector homeobox protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17222401	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17222401	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	32533114	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17222401	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17222401	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10037502	MGI
acts upstream of neuron apoptotic process	IDA IDA: Inferred from direct assay	10037502	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	32533114	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	32533114	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	32533114	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17222401	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10037502	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

activity-dependent neuroprotector homeobox protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105066	Davunetide		99.64%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00389	ADNP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18122	Adnp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24596	Adnp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adnp	NCBI	NCBI:23394

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