2. Gene
  3. Add2 - adducin 2 (beta) Gene

Add2 - adducin 2 (beta) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as add97; 2900072M03Rik

Gene ID: 11519 | Gene type: protein coding

About Add2

Summary

This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and Calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]

Add2 Products(6)

mRNA Protein Name
NM_001271857.1 NP_001258786.1 beta-adducin isoform 1
NM_001271858.1 NP_001258787.1 beta-adducin isoform 1
NM_001271859.1 NP_001258788.1 beta-adducin isoform 1
NM_001271860.1 NP_001258789.1 beta-adducin isoform 2
NM_001271861.1 NP_001258790.1 beta-adducin isoform 2
NM_013458.5 NP_038486.2 beta-adducin isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
10485892 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
10485892 MGI
involved in synapse assembly IDA
IDA: Inferred from direct assay
21435558 MGI
involved in synapse assembly IEP
IEP: Inferred from expression pattern
21435558 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
21435558 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
10485892 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-adducin

erythrocyte adducin subunit beta

snoRNA MBII-396

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00339 ADD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18905 Add2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25396 Add2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add2 NCBI NCBI:119