Adam2 - a disintegrin and metallopeptidase domain 2 Gene

Mus musculus

Also known as Ftnb; Ph30-beta

Gene ID: 11495 | Gene type: protein coding

About Adam2

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]

Adam2 Products(1)

mRNA	Protein	Name
NM_009618.3	NP_033748.2	disintegrin and metalloproteinase domain-containing protein 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15194697	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	16504143	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	21060781	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	16407499	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19129510	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	16504143	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell surface	IDA IDA: Inferred from direct assay	16407499	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21273369	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19129510	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 2

a disintegrin and metalloprotease domain 2 (fertilin beta)

fertilin subunit beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00276	ADAM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22377	Adam2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28901	Adam2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam2	NCBI	NCBI:2515

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