Adam19 - a disintegrin and metallopeptidase domain 19 (meltrin beta) Gene

Mus musculus

Also known as MTLNB; Mltnb; MADDAM

Gene ID: 11492 | Gene type: protein coding

About Adam19

Summary

This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]

Adam19 Products(4)

mRNA	Protein	Name
NM_001291890.1	NP_001278819.1	disintegrin and metalloproteinase domain-containing protein 19 isoform 2
NM_001291891.1	NP_001278820.1	disintegrin and metalloproteinase domain-containing protein 19 isoform 3
NM_001311209.1	NP_001298138.1	disintegrin and metalloproteinase domain-containing protein 19 isoform 4
NM_009616.4	NP_033746.1	disintegrin and metalloproteinase domain-containing protein 19 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	14673146	MGI
acts upstream of or within membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	11116142	MGI
acts upstream of or within membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	11116142	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11116142	MGI
NOT located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11116142	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 19

MDC beta	Mel beta
a disintegrin and metalloproteinase domain 19 (meltrin beta)	adamalysin 19

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00275	ADAM19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18194	Adam19 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24668	Adam19 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam19	NCBI	NCBI:8728

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