2. Gene
  3. Macf1 - microtubule-actin crosslinking factor 1 Gene

Macf1 - microtubule-actin crosslinking factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acf7; MACF; Aclp7; ABP620; mKIAA0465; mKIAA0754; D830031N03Rik

Gene ID: 11426 | Gene type: protein coding

About Macf1

Summary

Enables actin binding activity and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Macf1 Products(4)

mRNA Protein Name
NM_001199136.2 NP_001186065.1 microtubule-actin cross-linking factor 1 isoform 1
NM_001199137.2 NP_001186066.1 microtubule-actin cross-linking factor 1 isoform 2
NM_001401293.2 NP_001388222.1 microtubule-actin cross-linking factor 1 isoform 3
NM_001401294.2 NP_001388223.1 microtubule-actin cross-linking factor 1 isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
18854161 MGI
enables actin binding IDA
IDA: Inferred from direct assay
14636561 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
14636561 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16815997 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16815997 MGI
acts upstream of or within Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16815997 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
14636561 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
14636561 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
16815997 MGI
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16815997 MGI
acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane IMP
IMP: Inferred from mutant phenotype
16815997 MGI
involved in regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
18854161 MGI
involved in regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
18854161 MGI
involved in regulation of microtubule-based process IMP
IMP: Inferred from mutant phenotype
21295697 MGI
involved in regulation of neuron projection arborization IMP
IMP: Inferred from mutant phenotype
26526844 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
18854161 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
14636561 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21295697 MGI
located in microtubule IDA
IDA: Inferred from direct assay
18854161 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
14636561 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-actin cross-linking factor 1

actin cross-linking family 7

actin-crosslinking protein 7

trabeculin alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07942 MACF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22621 Macf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Macf1 NCBI NCBI:23499