2. Gene
  3. Ryr1 - ryanodine receptor 1 Gene

Ryr1 - ryanodine receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RYR-1; Ryr1l

Gene ID: 114207 | Gene type: protein coding

About Ryr1

Summary

Enables ryanodine-sensitive calcium-release channel activity. Involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to estradiol; and response to purine-containing compound. Located in sarcolemma; sarcoplasmic reticulum membrane; and terminal cisterna. Is extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in central core disease; malignant hyperthermia; and multiminicore disease. Orthologous to human RYR1 (ryanodine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ryr1 Products(4)

mRNA Protein Name
XM_039100854.1 XP_038956782.1 ryanodine receptor 1 isoform X4
XM_039100852.1 XP_038956780.1 ryanodine receptor 1 isoform X2
XM_039100853.1 XP_038956781.1 ryanodine receptor 1 isoform X3
XM_039100851.1 XP_038956779.1 ryanodine receptor 1 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16176928 RGD
enables ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
11316255 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion transport IDA
IDA: Inferred from direct assay
19116207 RGD
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
11316255 RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
32619649 RGD
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
19116207 RGD
involved in regulation of response to osmotic stress IMP
IMP: Inferred from mutant phenotype
19398777 RGD
involved in release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
19116207 RGD
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
11316255 RGD
involved in response to caffeine IDA
IDA: Inferred from direct assay
19116207 RGD
involved in response to caloric restriction IEP
IEP: Inferred from expression pattern
9742952 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
23111891 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19593990 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
24692174 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
30465874 RGD
involved in sarcoplasmic reticulum calcium ion transport IDA
IDA: Inferred from direct assay
19230144 RGD
involved in skeletal muscle contraction IEP
IEP: Inferred from expression pattern
21993782 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18005397 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
24692174 RGD
located in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20177054 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24692174 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
21474431 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
28044347 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
19230144 RGD
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11316255 RGD
located in terminal cisterna IDA
IDA: Inferred from direct assay
11316255 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18005397 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ryanodine receptor 1

ryanodine receptor 1 (skeletal)

ryanodine receptor 1, skeletal muscle

ryanodine receptor 1-like, skeletal muscle

skeletal muscle calcium release channel

skeletal muscle ryanodine receptor

skeletal muscle-type ryanodine receptor

type 1 ryanodine rece

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12542 Dantrolene Inhibitor ≥98.0% Yes
HY-12542A Dantrolene sodium hemiheptahydrate Inhibitor 99.79% Yes
HY-14657 Dantrolene sodium Inhibitor 99.79% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5114A Maurocalcine TFA Agonist 95.19% Unkown
HY-P5114 Maurocalcine Agonist / Unkown
HY-119581 MBED / Unkown
HY-P5424 RyR1(3614-3643) / Unkown
HY-RS12368 RYR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19950 Ryr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26452 Ryr1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ryr1 NCBI NCBI:6261