Inpp5e - inositol polyphosphate-5-phosphatase E Gene

Rattus norvegicus

Gene ID: 114089 | Gene type: protein coding

About Inpp5e

Summary

Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate Phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase signaling and negative regulation of translation. Located in cytoplasm; plasma membrane; and ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5e Products(1)

mRNA	Protein	Name
NM_053632.1	NP_446084.1	phosphatidylinositol polyphosphate 5-phosphatase type IV

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol-polyphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	10405344	RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA IDA: Inferred from direct assay	21436142	RGD
enables phosphatidylinositol-4,5-bisphosphate phosphatase activity	IDA IDA: Inferred from direct assay	21436142	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21436142	RGD
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	21436142	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in ruffle	IDA IDA: Inferred from direct assay	10405344	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol polyphosphate 5-phosphatase type IV

5-phosphatase that induces arborization	72 kDa inositol polyphosphate 5-phosphatase
inositol polyphosphate 5-phosphatase	pharbin
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase	phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06830	INPP5E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21143	Inpp5e Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27660	Inpp5e Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inpp5e	NCBI	NCBI:56623

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