C5ar1 - complement C5a receptor 1 Gene

Rattus norvegicus

Also known as C5aR; C5r1; C5a-R

Gene ID: 113959 | Gene type: protein coding

About C5ar1

Summary

Enables complement component C5a binding activity and complement component C5a receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of neuron apoptotic process; and response to lipopolysaccharide. Located in cell surface and plasma membrane. Used to study adult respiratory distress syndrome; amyotrophic lateral sclerosis; neutropenia; obesity; and thrombosis. Biomarker of asthma and lung disease. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

C5ar1 Products(1)

mRNA	Protein	Name
NM_053619.2	NP_446071.1	C5a anaphylatoxin chemotactic receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables complement component C5a binding	IDA IDA: Inferred from direct assay	15292245	RGD
enables complement component C5a receptor activity	IDA IDA: Inferred from direct assay	9464523	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	15322206	RGD
involved in cell proliferation in hindbrain	IMP IMP: Inferred from mutant phenotype	18635264	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15292245	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15292245	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	9272704	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	15322206	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9464523	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C5a anaphylatoxin chemotactic receptor 1

complement component 5, receptor 1

complement component 5a receptor 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106178	PMX-53	Antagonist	99.98%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99450	Avdoralimab	Inhibitor	99.25%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110136A	PMX 205 Trifluoroacetate	Antagonist	99.50%	Unkown
HY-148141	JPE-1375	Antagonist	99.96%	Unkown
HY-145237	BM213	Agonist	99.81%	Unkown
HY-P10639	C5aR2 agonist P32	Agonist	99.82%	Unkown
HY-163378	C5aR1 antagonist 1	Antagonist	/	Unkown
HY-163379	C5aR1 antagonist 2	Antagonist	/	Unkown
HY-RS01750	C5AR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10639A	C5aR2 agonist P32 acetate	Agonist	/	Unkown
HY-RS18377	C5ar1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24857	C5ar1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W130878	4-Octylphenol	Activator	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990745	Izastobart	Ligand	/	Unkown
HY-P991485	Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	C5ar1	NCBI	NCBI:728

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