2. Gene
  3. Acadvl - acyl-Coenzyme A dehydrogenase, very long chain Gene

Acadvl - acyl-Coenzyme A dehydrogenase, very long chain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as vlcad

Gene ID: 11370 | Gene type: protein coding

About Acadvl

Summary

This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

Acadvl Products(1)

mRNA Protein Name
NM_017366.3 NP_059062.1 very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
IMP: Inferred from mutant phenotype
15639194 MGI
acts upstream of or within fatty acid catabolic process IMP
IMP: Inferred from mutant phenotype
21151927 MGI
involved in negative regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
15639194 MGI
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
15639194 MGI
involved in regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
15639194 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
21151927 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
15639194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

very long-chain specific acyl-CoA dehydrogenase, mitochondrial

MVLCAD

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00131 ACADVL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19760 Acadvl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26257 Acadvl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acadvl NCBI NCBI:37