Acadm - acyl-Coenzyme A dehydrogenase, medium chain Gene

Mus musculus

Also known as MCAD

Gene ID: 11364 | Gene type: protein coding

About Acadm

Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]

Acadm Products(1)

mRNA	Protein	Name
NM_007382.5	NP_031408.1	medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables medium-chain fatty acyl-CoA dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	18459129	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16121256	MGI
acts upstream of or within carnitine metabolic process	IMP IMP: Inferred from mutant phenotype	16121256	MGI
involved in carnitine metabolic process, CoA-linked	IMP IMP: Inferred from mutant phenotype	18459129	MGI
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IMP IMP: Inferred from mutant phenotype	18459129	MGI
involved in glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	18459129	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16121256	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	16121256	MGI
involved in medium-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	18459129	MGI
acts upstream of or within organic acid metabolic process	IMP IMP: Inferred from mutant phenotype	16121256	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16121256	MGI
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	18459129	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	16121256	MGI
acts upstream of or within response to starvation	IMP IMP: Inferred from mutant phenotype	16121256	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	26767982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00128	ACADM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17544	Acadm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24002	Acadm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acadm	NCBI	NCBI:34

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