2. Gene
  3. Pde6c - phosphodiesterase 6C, cGMP specific, cone, alpha prime Gene

Pde6c - phosphodiesterase 6C, cGMP specific, cone, alpha prime Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cpfl1

Gene ID: 110855 | Gene type: protein coding

About Pde6c

Summary

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within phototransduction, visible light; retinal cone cell development; and visual perception. Predicted to be located in plasma membrane. Is expressed in brain and retina. Used to study achromatopsia. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human PDE6C (phosphodiesterase 6C). [provided by Alliance of Genome Resources, Apr 2022]

Pde6c Products(2)

mRNA Protein Name
NM_001170959.1 NP_001164430.1 cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 2
NM_033614.2 NP_291092.1 cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within phototransduction, visible light IMP
IMP: Inferred from mutant phenotype
16723493 MGI
acts upstream of or within retinal cone cell development IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within sensory perception of light stimulus IMP
IMP: Inferred from mutant phenotype
16723493 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
22937111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

cGMP phosphodiesterase 6C

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-RS10234 PDE6C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21685 Pde6c Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde6c NCBI NCBI:5146