2. Gene
  3. Foxe1 - forkhead box E1 Gene

Foxe1 - forkhead box E1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TTF-2; Titf2

Gene ID: 110805 | Gene type: protein coding

About Foxe1

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cranial skeletal system development. Acts upstream of or within several processes, including animal organ development; roof of mouth development; and thyroid hormone generation. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial pouch endoderm; head surface ectoderm; and outflow tract. Used to study Bamforth-Lazarus syndrome and congenital hypothyroidism. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and thyroid gland papillary carcinoma. Orthologous to human FOXE1 (forkhead box E1). [provided by Alliance of Genome Resources, Apr 2022]

Foxe1 Products(1)

mRNA Protein Name
NM_183298.2 NP_899121.1 forkhead box protein E1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15581879 MGI
involved in cranial skeletal system development IMP
IMP: Inferred from mutant phenotype
21177256 MGI
acts upstream of or within embryonic organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9697704 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
15367491 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
22304410 MGI
involved in roof of mouth development IMP
IMP: Inferred from mutant phenotype
21177256 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
9697704 MGI
acts upstream of or within thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
9697704 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein E1

thyroid transcription factor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05047 FOXE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21574 Foxe1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxe1 NCBI NCBI:2304