Tmbim6 - transmembrane BAX inhibitor motif containing 6 Gene

Mus musculus

Also known as Bi1; Tegt; 5031406P05Rik

Gene ID: 110213 | Gene type: protein coding

About Tmbim6

Summary

Enables endoribonuclease inhibitor activity and enzyme binding activity. Involved in cellular response to unfolded protein; negative regulation of RNA metabolic process; and negative regulation of immunoglobulin production. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Is expressed in head and retina. Orthologous to human TMBIM6 (transmembrane Bax Inhibitor motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]

Tmbim6 Products(4)

mRNA	Protein	Name
NM_001171034.1	NP_001164505.1	bax inhibitor 1
NM_001171035.1	NP_001164506.1	bax inhibitor 1
NM_001171036.1	NP_001164507.1	bax inhibitor 1
NM_026669.4	NP_080945.1	bax inhibitor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables endoribonuclease inhibitor activity	IMP IMP: Inferred from mutant phenotype	19328063	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	19328063	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to unfolded protein	IMP IMP: Inferred from mutant phenotype	19328063	MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis	IDA IDA: Inferred from direct assay	15304216	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	15304216	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15304216	MGI
involved in negative regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	19328063	MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	22240901	MGI
involved in negative regulation of endoribonuclease activity	IMP IMP: Inferred from mutant phenotype	19328063	MGI
involved in negative regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	19328063	MGI
acts upstream of or within neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15304216	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21075086	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bax inhibitor 1

BI-1	testis enhanced gene transcript
testis-enhanced gene transcript protein	transmembrane BAX inhibitor motif-containing protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137175	TMBIM6 antagonist-1	Antagonist	99.60%	Unkown
HY-161388	NSCLC-IN-1	Inducer	/	Unkown
HY-RS14620	TMBIM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19822	Tmbim6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26318	Tmbim6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmbim6	NCBI	NCBI:7009

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