E2f8 - E2F transcription factor 8 Gene

Mus musculus

Also known as 4432406C08Rik

Gene ID: 108961 | Gene type: protein coding

About E2f8

Summary

Enables DNA binding activity; DNA-binding transcription repressor activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within cell population proliferation. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]

E2f8 Products(2)

mRNA	Protein	Name
NM_001013368.5	NP_001013386.2	transcription factor E2F8
NM_001360812.1	NP_001347741.1	transcription factor E2F8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15722552	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22516201	MGI
enables DNA-binding transcription repressor activity	IMP IMP: Inferred from mutant phenotype	22516201	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15722552	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell cycle comprising mitosis without cytokinesis	IMP IMP: Inferred from mutant phenotype	23064266	MGI
involved in chorionic trophoblast cell differentiation	IMP IMP: Inferred from mutant phenotype	22516201	MGI
acts upstream of or within fibroblast proliferation	IDA IDA: Inferred from direct assay	15722552	MGI
involved in hepatocyte differentiation	IMP IMP: Inferred from mutant phenotype	23064264	MGI
involved in negative regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	23064264	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22516201	MGI
involved in placenta development	IMP IMP: Inferred from mutant phenotype	22516201	MGI
involved in positive regulation of DNA endoreduplication	IMP IMP: Inferred from mutant phenotype	23064264	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	22903062	MGI
involved in trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	23064266	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15722552	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor E2F8

E2f family member 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04117	E2F8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22149	E2f8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	E2f8	NCBI	NCBI:79733

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