2. Gene
  3. Prkaa2 - protein kinase, AMP-activated, alpha 2 catalytic subunit Gene

Prkaa2 - protein kinase, AMP-activated, alpha 2 catalytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as A830082D05; AMPKalpha2; 2310008I11Rik

Gene ID: 108079 | Gene type: protein coding

About Prkaa2

Summary

Enables AMP-activated protein kinase activity; chromatin binding activity; and histone serine kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa2 Products(2)

mRNA Protein Name
NM_001356568.1 NP_001343497.1 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 2
NM_178143.2 NP_835279.2 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AMP-activated protein kinase activity IDA
IDA: Inferred from direct assay
18439900 MGI
enables AMP-activated protein kinase activity IGI
IGI: Inferred from genetic interaction
25788287 MGI
enables AMP-activated protein kinase activity IMP
IMP: Inferred from mutant phenotype
16308421 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20647423 MGI
enables histone H2BS36 kinase activity IDA
IDA: Inferred from direct assay
20647423 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19833968 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
32912901 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16308421 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to calcium ion IGI
IGI: Inferred from genetic interaction
25788287 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
21258367 MGI
involved in cellular response to glucose stimulus IGI
IGI: Inferred from genetic interaction
25788287 MGI
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
21258367 MGI
involved in cellular response to oxidative stress IGI
IGI: Inferred from genetic interaction
27430620 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IGI
IGI: Inferred from genetic interaction
23479225 MGI
acts upstream of or within cellular response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
23918774 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16308421 MGI
involved in lipid biosynthetic process IDA
IDA: Inferred from direct assay
21459323 MGI
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
18439900 MGI
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
32912901 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18439900 MGI
involved in negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
27430620 MGI
involved in negative regulation of tubulin deacetylation IGI
IGI: Inferred from genetic interaction
27430620 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
21258367 MGI
involved in positive regulation of peptidyl-lysine acetylation IGI
IGI: Inferred from genetic interaction
27430620 MGI
involved in positive regulation of protein localization IGI
IGI: Inferred from genetic interaction
27430620 MGI
involved in protein localization to lipid droplet IDA
IDA: Inferred from direct assay
34077757 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
23332761 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
19833968 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23918774 MGI
involved in regulation of macroautophagy IDA
IDA: Inferred from direct assay
23332761 MGI
involved in regulation of microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
27430620 MGI
involved in regulation of stress granule assembly IGI
IGI: Inferred from genetic interaction
27430620 MGI
acts upstream of or within response to muscle activity IMP
IMP: Inferred from mutant phenotype
23918774 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IGI
IGI: Inferred from genetic interaction
25788287 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
30201684 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
27430620 MGI
located in dendrite IGI
IGI: Inferred from genetic interaction
25788287 MGI
located in neuronal cell body IGI
IGI: Inferred from genetic interaction
25788287 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10098881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-2

ACACA kinase

AMPK subunit alpha-2

HMGCR kinase

acetyl-CoA carboxylase kinase

hydroxymethylglutaryl-CoA reductase kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11101 PRKAA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21177 Prkaa2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkaa2 NCBI NCBI:5563