Rrn3 - RRN3 RNA polymerase I transcription factor homolog (yeast) Gene

Mus musculus

Also known as Tif1a; TIF-1A; E130302O19Rik

Gene ID: 106298 | Gene type: protein coding

About Rrn3

Summary

Enables RNA polymerase binding activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of transcription, DNA-templated; and transcription initiation from RNA polymerase I promoter. Predicted to be located in nucleolus. Predicted to be active in nucleus. Used to study Parkinson's disease. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rrn3 Products(1)

mRNA	Protein	Name
NM_001039521.1	NP_001034610.1	RNA polymerase I-specific transcription initiation factor RRN3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase binding	IDA IDA: Inferred from direct assay	8413268	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	8413268	MGI
acts upstream of or within cytoplasm organization	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within nucleolus organization	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8413268	MGI
acts upstream of or within regulation of DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	8413268	MGI
acts upstream of or within ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	15989966	MGI
acts upstream of or within transcription initiation at RNA polymerase I promoter	IMP IMP: Inferred from mutant phenotype	15989966	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RNA polymerase I-specific transcription initiation factor RRN3

transcription initiation factor TIF-IA

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12288	RRN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18787	Rrn3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25276	Rrn3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rrn3	NCBI	NCBI:54700

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