2. Gene
  3. Espl1 - extra spindle pole bodies 1, separase Gene

Espl1 - extra spindle pole bodies 1, separase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SSE; Cerp; ESP1; PRCE

Gene ID: 105988 | Gene type: protein coding

About Espl1

Summary

Enables cysteine-type peptidase activity. Acts upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study breast Cancer. Orthologous to human ESPL1 (extra spindle pole bodies like 1, Separase). [provided by Alliance of Genome Resources, Apr 2022]

Espl1 Products(2)

mRNA Protein Name
NM_001014976.2 NP_001014976.1 separin
NM_001356312.1 NP_001343241.1 separin
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
23975099 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
19625504 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chromosome segregation IGI
IGI: Inferred from genetic interaction
16533945 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within meiosis I IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within meiotic spindle organization IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within mitotic cell cycle IGI
IGI: Inferred from genetic interaction
23975099 MGI
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
16533945 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

separin

Cut1/ESP1 related protein

caspase-like protein ESPL1

extra spindle poles-like 1 protein

separase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04527 ESPL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19433 Espl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25924 Espl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espl1 NCBI NCBI:9700