2. Gene
  3. BPNT1 - 3'(2'), 5'-bisphosphate nucleotidase 1 Gene

BPNT1 - 3'(2'), 5'-bisphosphate nucleotidase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PIP; HEL20

Gene ID: 10380 | Gene type: protein coding

About BPNT1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,057,482-220,089,788 (from NCBI)

This gene has 11 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 11.4), duodenum (RPKM 10.5) and 24 other tissues.

Summary

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

BPNT1 Products(4)

mRNA Protein Name
NM_001286149.2 NP_001273078.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
NM_001286150.2 NP_001273079.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform 3
NM_001286151.2 NP_001273080.1 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
NM_006085.6 NP_006076.4 3'(2'),5'-bisphosphate nucleotidase 1 isoform 1

BPNT1 Protein Structure

Inositol_P

Inositol_P: Inositol monophosphatase family (13 - 296)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

3'(2'),5'-bisphosphate nucleotidase 1

BPntase

Related Diseases

Diseases Alias
Ring Dermoid Of Cornea

RDC

Ring Dermoid Syndrome

Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

Dermoid Of Cornea, Ring
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01585 BPNT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BPNT1 MGD MGI:1338800
Macaca mulatta BPNT1 VGNC VGNC:99851
Felis catus BPNT1 VGNC VGNC:107844
Rattus norvegicus BPNT1 RGD RGD:621833
Canis familiaris BPNT1 VGNC VGNC:53113