Ano1 - anoctamin 1, calcium activated chloride channel Gene

Mus musculus

Also known as Tmem16a

Gene ID: 101772 | Gene type: protein coding

About Ano1

Summary

Enables intracellular calcium activated Chloride Channel activity; protein homodimerization activity; and voltage-gated Chloride Channel activity. Involved in several processes, including chloride transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within regulation of membrane potential. Located in apical plasma membrane and external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ano1 Products(2)

mRNA	Protein	Name
NM_001242349.2	NP_001229278.2	anoctamin-1 isoform 2
NM_178642.6	NP_848757.5	anoctamin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride channel activity	IDA IDA: Inferred from direct assay	25779870	MGI
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	24885604	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	23576756	MGI
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	18724360	MGI
NOT enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	23532839	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23576756	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28561733	MGI
enables voltage-gated chloride channel activity	IDA IDA: Inferred from direct assay	22634729	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to heat	IDA IDA: Inferred from direct assay	22634729	MGI
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	22634729	MGI
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	24885604	MGI
acts upstream of or within chloride transport	IDA IDA: Inferred from direct assay	20056604	MGI
involved in chloride transport	IDA IDA: Inferred from direct assay	18724360	MGI
involved in chloride transport	IMP IMP: Inferred from mutant phenotype	28963502	MGI
NOT involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	22634729	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IGI IGI: Inferred from genetic interaction	22634729	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	22634729	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	23532839	MGI
involved in glial cell projection elongation	IMP IMP: Inferred from mutant phenotype	31147466	MGI
involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	30586313	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22634729	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24885604	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	23133519	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	23133519	MGI
involved in trachea development	IMP IMP: Inferred from mutant phenotype	18585372	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21516098	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23576756	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23840801	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18585372	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	23840801	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

anoctamin-1

transmembrane protein 16A

Ano1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ano1	Q8BHY3	Ano1	Mus musculus	Q8BHY3	3D-EM-Single	29236691
Intra	Ano1	Q8BHY3	Ano1	Mus musculus	Q8BHY3	3D-EM	29236684

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100612	T16Ainh-A01	Inhibitor	≥99.0%	Unkown
HY-119981	Ani9	Inhibitor	99.12%	Unkown
HY-146334	DFBTA	Inhibitor	99.25%	Unkown
HY-146320	ANO1-IN-1	Inhibitor	99.57%	Unkown
HY-105917	Emidurdar	Inhibitor	99.41%	Yes
HY-118170	T16A(inh)-C01	Inhibitor	90%	Unkown
HY-N5101	Kobusin		99.93%	Unkown
HY-146321	ANO1-IN-2	Inhibitor	/	Unkown
HY-147874	ANO1-IN-3		/	Unkown
HY-153508	ANO1-IN-4	Inhibitor	/	Unkown
HY-RS00740	ANO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00750	ANOS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17326	Ano1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23781	Ano1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990337	Anti-ANO1/TMEM16A Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ano1	NCBI	NCBI:55107

Name
Email *

	Sorry, but the email address you supplied was invalid.