1. Gene
  2. APELA - apelin receptor early endogenous ligand Gene

APELA - apelin receptor early endogenous ligand Gene

Homo sapiens

Also known as ELA; tdl; Ende

Gene ID: 100506013 | Gene type: protein coding

About APELA

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:164,877,178-164,899,007 (from NCBI)

This gene has 5 transcripts (splice variants) and 16 orthologues. Biased expression in prostate (RPKM 1.8), kidney (RPKM 0.5) and 2 other tissues.

Summary

This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/Akt pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]

APELA Products(1)

mRNA Protein Name
NM_001297550.2 NP_001284479.1 apelin receptor early endogenous ligand precursor
Protein Preferred Names Protein Names

apelin receptor early endogenous ligand

protein Elabela

Related Diseases

Diseases Alias
Thyroid Cancer, Nonmedullary, 1

Papillary Thyroid Carcinoma

Familial Nonmedullary Thyroid Cancer, Papillary

Nonmedullary Thyroid Carcinoma, Papillary

Papillary Thyroid Cancer

NMTC1

Papillary Carcinoma Of Thyroid

Pact

Thyroid Carcinoma, Papillary

Non-Medullary Thyroid Carcinoma

Thyroid Cancer, Non-Medullary, 1

Familial Non-Medullary Thyroid Cancer

Fnmtc

Nmtc

Nonmedullary Thyroid Carcinoma

Ptc

Tpc

Thyroid Papillary Carcinoma

Cancer, Thyroid, Nonmedullary

Cancer, Thyroid, Nonmedullary, Type 1

Thyroid Carcinoma, Nonmedullary 1

Familial Nonmedullary Thyroid Gland Carcinoma

Papillary Carcinoma, Diffuse Sclerosing, Thyroid Gland

46,Xy Sex Reversal 8

SRXY8

Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

Tdd

46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

46xy Sex Reversal 8

46xy Sex Reversal 8, Modifier Of

Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

N Syndrome

NSX

Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma