1. Gene
  2. SLC17A4 - solute carrier family 17 member 4 Gene

SLC17A4 - solute carrier family 17 member 4 Gene

Homo sapiens

Also known as KAIA2138

Gene ID: 10050 | Gene type: protein coding

About SLC17A4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:25,754,699-25,781,199 (from NCBI)

This gene has 3 transcripts (splice variants), 400 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues.

Summary

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

SLC17A4 Products(2)

mRNA Protein Name
NM_001286121.1 NP_001273050.1 probable small intestine urate exporter isoform b
NM_005495.3 NP_005486.1 probable small intestine urate exporter isoform a

SLC17A4 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (45 - 444)

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  • 497 a.a.
Protein Preferred Names Protein Names

probable small intestine urate exporter

Na/PO4 cotransporter

Orthologs Information

Species Symbol Source ID
Mus musculus SLC17A4 MGD MGI:2442850
Felis catus SLC17A4 VGNC VGNC:65220
Bos taurus SLC17A4 VGNC VGNC:34699
Rattus norvegicus SLC17A4 RGD RGD:1584758
Canis familiaris SLC17A4 VGNC VGNC:59140
Macaca mulatta SLC17A4 VGNC VGNC:77404