2. Gene
  3. Isg15 - ISG15 ubiquitin-like modifier Gene

Isg15 - ISG15 ubiquitin-like modifier Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as G1p2; IP17; Irfp; UCRP; IGI15

Gene ID: 100038882 | Gene type: protein coding

About Isg15

Summary

Enables protein tag. Involved in several processes, including ISG15-protein conjugation; defense response to Other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]

Isg15 Products(1)

mRNA Protein Name
NM_015783.3 NP_056598.2 ubiquitin-like protein ISG15
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15485925 MGI
enables protein tag activity IDA
IDA: Inferred from direct assay
16139798 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within ISG15-protein conjugation IDA
IDA: Inferred from direct assay
16139798 MGI
involved in ISG15-protein conjugation IDA
IDA: Inferred from direct assay
22022510 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
22859821 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
17227866 MGI
acts upstream of or within modification-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15485925 MGI
involved in positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
21402791 MGI
involved in positive regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22022510 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like protein ISG15

interferon, alpha-inducible protein

interferon-induced 15 kDa protein

interferon-induced 15-KDa protein

interferon-induced 17 kDa protein

interferon-stimulated protein (15 kDa)

interferon-stimulated protein 15

ubiquitin cross-reactive protein

Isg15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Isg15 Q64339 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Cleavage
32726803
Cross
Isg15 Q64339 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Probe Interaction
32726803
Cross
Isg15 Q64339 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Cleavage
32726803
Cross
Isg15 Q64339 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
X-Ray Diffraction
32726803
Cross
Isg15 Q64339 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Protease Assay
32428392
Cross
Isg15 Q64339 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Protease Assay
32428392
Cross
Isg15 Q64339 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Probe Interaction
32726803
Intra
Isg15 Q64339 Usp18 Mus musculus Q9WTV6
Enzymatic Study
24533902
Intra
Isg15 Q64339 Usp18 Mus musculus Q9WTV6
MST
24533902
Intra
Isg15 Q64339 Usp18 Mus musculus Q9WTV6
Probe Interaction
32726803
Intra
Isg15 Q64339 Usp18 Mus musculus Q9WTV6
Cleavage
32726803
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152956 STING agonist-23 Agonist 99.16% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-172193 UBD1031 Ligand / Unkown
HY-172969 ZHAWOC8655 Inhibitor / Unkown
HY-RS06929 ISG15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17041 Isg15 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23485 Isg15 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isg15 NCBI NCBI:9636