2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Protein Tyrosine Kinase/RTK
  3. iGluR Reactive Oxygen Species Trk Receptor
  4. FLY26

FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury.

For research use only. We do not sell to patients.

FLY26 Chemical Structure

FLY26 Chemical Structure

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FLY26 Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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TrkA TrkB TrkC Trk

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Description

FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury[1].

IC50 & Target

TrkB

 

NMDA Receptor

 

Molecular Weight

405.45

Formula

C22H23N5O3
SMILES

O=C(OCC)C1=CN(C=C(C2=CC=C(N=CN(CCN(C)C)C3=O)C3=C2)C=C4)C4=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLY26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLY26FLY 26FLY-26iGluRReactive Oxygen SpeciesTrk ReceptorIonotropic glutamate receptorsTropomyosin related kinase receptorGluN2BNMDA receptorscalcium ionROSneurological deficitsInhibitorinhibitorinhibit

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