2. Immunology/Inflammation
  3. FAP
  4. FAPI-JNU

FAPI-JNU is a molecule targeting fibroblast activation protein (FAP). FAPI-JNU specifically binds to FAP highly expressed in the tumor microenvironment, and uses radionuclides [68Ga]Ga or [177Lu]Lu to achieve tumor imaging diagnosis. [177Lu]Lu−FAPI−JNU can effectively target and inhibit tumor growth in tumor-bearing mice. FAPI-JNU is promising for research of FAP-positive tumors (such as various solid tumors).

For research use only. We do not sell to patients.

FAPI-JNU Chemical Structure

FAPI-JNU Chemical Structure

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FAPI-JNU Related Antibodies

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Description

FAPI-JNU is a molecule targeting fibroblast activation protein (FAP). FAPI-JNU specifically binds to FAP highly expressed in the tumor microenvironment, and uses radionuclides [68Ga]Ga or [177Lu]Lu to achieve tumor imaging diagnosis. [177Lu]Lu−FAPI−JNU can effectively target and inhibit tumor growth in tumor-bearing mice. FAPI-JNU is promising for research of FAP-positive tumors (such as various solid tumors)[1].

Molecular Weight

2253.49

Formula

C107H153F4N23O26
SMILES

O=C(CN(CCN(CC(N[C@H](C(N[C@H](C(NCCOCCOCCOCCOCC(N1CCN(CC1)CCCN(C2=CC=C(C3=C2)N=CC=C3C(NCC(N4CC(F)(C[C@]4(C#N)[H])F)=O)=O)C)=O)=O)CCCCNC(CCCC5=CC=C(C=C5)O)=O)=O)CCC(NCCOCCOCCOCCOCC(N6CCN(CC6)CCCN(C7=CC=C(C8=C7)N=CC=C8C(NCC(N9CC(F)(C[C@]9(C#N)[H])F)=O)=O)C)=O)=O)=O)CCN(CC%10)CC(O)=O)CCN%10CC(O)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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FAPI-JNU Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAPI-JNUFAPFibroblast activation proteintumor microenvironmenttumorInhibitorinhibitorinhibit

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