2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ERα antagonist 2

ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC50 value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer.

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ERα antagonist 2

ERα antagonist 2 Chemical Structure

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ERα antagonist 2 Related Antibodies

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Description

ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC50 value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer[1].

IC50 & Target[1]

ERα

1729 nM (IC50)

Molecular Weight

802.96

Formula

C46H38N6O4S2
SMILES

CC(C=C1)=CC=C1S(N(C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=NN5S(C6=CC=C(C)C=C6)(=O)=O)N=C5C7=CN(C8=C7C=CC=C8)CC9=CC=CC=C9)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERα antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERα antagonist 2ERα antagonist2ERα antagonist-2Estrogen Receptor/ERRbis(indolyl)-tetrazine derivativesbreast canceranti-proliferative activityestrogen receptor-alphaCYP3A inhibitiondrug designstructure-activity relationshipcytotoxicitymolecular dockingSERMsInhibitorinhibitorinhibit

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ERα antagonist 2
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HY-179232
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