EGFR/VEGFR2-IN-8 

EGFR/VEGFR2-IN-8 is a dual EGFR/VEGFR-2 inhibitor (EGFR IC₅₀ = 57 nM, VEGFR-2 IC₅₀ = 21 nM). EGFR/VEGFR2-IN-8 has anti proliferative activity against various tumor cells, such as MCF-7 (IC₅₀ = 20 nM), Panc-1 (IC₅₀ = 22 nM), A-549 (IC₅₀ = 23 nM), HT-29 (IC₅₀ = 23 nM) cells. EGFR/VEGFR2-IN-8 has antioxidant and apoptosis inducing activity. EGFR/VEGFR2-IN-8 can be used for research on various types of cancer^[1].

451.89

C₂₁H₁₄ClN₅O₃S

N#CC1=C(C2=CC=C(OC)C=C2)N=C(SCC3=NC(C4=CC=C(Cl)C=C4)=NO3)NC1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Al-Wahaibi LH, et al. Design, synthesis, and apoptotic antiproliferative activity of novel dihydropyrimidine-5-carbonitrile/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors endowed with antioxidant activity. RSC Adv. 2025 Oct 16;15(46):38998-39027.  [Content Brief]