2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. (E)-FOBISIN101

(E)-FOBISIN101 is a 14-3-3 protein inhibitor (14-3-3γ IC50 = 16.4 μM; 14-3-3ζ IC50 = 9.3 μM). (E)-FOBISIN101 inhibits the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase. (E)-FOBISIN101 can be used for 14-3-3-mediated cancer research.

For research use only. We do not sell to patients.

(E)-FOBISIN101

(E)-FOBISIN101 Chemical Structure

CAS No. : 1370281-06-3

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(E)-FOBISIN101 Related Antibodies

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Description

(E)-FOBISIN101 is a 14-3-3 protein inhibitor (14-3-3γ IC50 = 16.4 μM; 14-3-3ζ IC50 = 9.3 μM). (E)-FOBISIN101 inhibits the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase. (E)-FOBISIN101 can be used for 14-3-3-mediated cancer research[1].

IC50 & Target[1]

14-3-3γ

16.4 μM (IC50)

14-3-3ζ

9.3 μM (IC50)

Molecular Weight

461.21

Formula

C15H11N3Na3O8P
CAS No.
SMILES

O=C(O[Na])C(C=C1)=CC=C1/N=N/C2=C(COP(O[Na])(O[Na])=O)C(C=O)=C(C(C)=N2)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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(E)-FOBISIN101 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-FOBISIN1011370281-06-3Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteases14-3-3γRaf-1proline-rich AKTexoenzyme SADP-ribosyltransferaseInhibitorinhibitorinhibit

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