2. Anti-infection
  3. Antibiotic Bacterial Penicillin-binding protein (PBP)
  4. DQ 2556

DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.

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DQ 2556

DQ 2556 Chemical Structure

CAS No. : 102253-70-3

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DQ 2556 Related Antibodies

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Description

DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins[1][2].
IC50 & Target[1][2]

β-lactam

 

In Vitro

DQ-2556 is active against Gram-positive bacteria, sensitive to methicillin-resistant Staphylococcus (MIC90 = 1.56-3.13 μg/mL), highly active against Streptococcus (MIC90 ≤ 0.05 μg/mL), and has limited activity against Enterococcus (MIC90 = 50 μg/mL)[1][2].
DQ-2556 is active against Gram-negative bacteria, has an MIC₉₀ value of no more than 0.05 μg/mL against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, etc. and sensitive to Haemophilus influenzae and Neisseria gonorrhoeae with MIC90 of 0.1 μg/mL[1][2].
DQ-2556 has the same or ≤ 4-fold MIC₉₀ value against Staphylococcus aureus, Escherichia coli, and Proteus mirabilis[1][2].
DQ-2556 (0.0008-12.5 μg, 4 h) induces the formation of filamentous and spherical structures in Escherichia coli, and also induced cell lysis at higher concentrations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DQ 2556 Related Antibodies
In Vivo

DQ-2556 (0.2 mL/mice, s.c., single dose) exhibits ED50s against infections with S. aureus, S. pneumoniae, E. coli, K pneumoniae, and S. marcescens of 0.37, 2.75, 0.0091, 0.23, and 0.029 mg/kg mg/kg of body weight, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

541.56

Formula

C22H19N7O6S2
CAS No.
SMILES

[O-]C(C1=C(C[N+]2=CC=C(C3=CN=CO3)C=C2)CS[C@@]([C@@H]4NC(/C(C5=CSC(N)=N5)=N\OC)=O)([H])N1C4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DQ 2556 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DQ 2556102253-70-3DQ2556DQ-2556AntibioticBacterialPenicillin-binding protein (PBP)MIC/MBC valuesgram-positive and gram-negative bacteriaβ-lactamase stabilityexperimental infectionspharmacokineticsInhibitorinhibitorinhibit

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