2. Disease Areas
  3. Infection
  4. Viral Infection

Viral Infection

Experimental viral infection involves studying viral pathogenesis in controlled environments, typically using animal models, to assess how factors like malnutrition influence viral replication, disease severity, and immune responses. Immunodeficiency-65 (IMD65) is an autosomal recessive disorder marked by severe viral infections beginning in infancy, leading to recurrent pneumonia, bronchiectasis, and septic shock due to defective type I interferon signaling. Key laboratory features include lymphopenia, hypogammaglobulinemia, and impaired antiviral immunity. Intravenous immunoglobulin therapy provides clinical benefit, while live attenuated vaccines are contraindicated due to the risk of vaccine-strain dissemination in patients with compromised interferon responses.

 

Viral Infection (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13637S
    Ganciclovir-d5 1189966-73-1 98.32%
    Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).
    Ganciclovir-d<sub>5</sub>