2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Oxidative Stress and Inflammation

Oxidative Stress and Inflammation

Oxidative stress arises from an imbalance between oxidants and antioxidants, resulting in excessive reactive oxygen species (ROS) that can damage lipids, proteins, and DNA. While unavoidable in an oxygen-rich environment, moderate oxidative stress is essential for normal cellular functions by regulating redox-sensitive signaling pathways such as OxyR and SoxR in bacteria, and NF-κB and Nrf2/Keap1 in higher organisms. In contrast, excessive oxidative stress leads to molecular damage and disruption of redox homeostasis, contributing to various pathological conditions. Additionally, controlled production of oxidants by immune cells serves as a defense mechanism against pathogens.

 

Oxidative Stress and Inflammation (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0385
    Gomisin J 66280-25-9 99.97%
    Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc.
    Gomisin J
  • HY-106262
    Delcasertib 949100-39-4 98.21%
    Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).
    Delcasertib
  • HY-P99886
    Pexelizumab 219685-93-5
    Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction.
    Pexelizumab