2. Disease Areas
  3. Digestive System Disease
  4. Liver Disease

Liver Disease

Liver disease refers to a broad spectrum of conditions that impair liver function, including viral hepatitis, fatty liver disease, autoimmune disorders, genetic mutations, drug-induced injury, and liver cancer. These conditions can lead to symptoms such as jaundice, abdominal swelling, dark urine, pale stools, fatigue, and portal hypertension, with progression potentially resulting in cirrhosis or liver failure. Common causes include viral infections (hepatitis A, B, C), excessive alcohol intake, obesity, metabolic syndrome, inherited disorders (e.g., hemochromatosis, Wilson disease), and exposure to hepatotoxic drugs or toxins. Diagnostic approaches involve liver function tests, imaging, and biopsy, while management varies from lifestyle modifications and pharmacotherapy to liver transplantation in advanced cases. Key genes implicated include MEG3, and pathways related to metabolism, steroid metabolism, and mitochondrial function are frequently involved. Associated tissues include the liver and bone marrow, with phenotypic features such as reduced mammosphere formation and biliary system dysfunction.

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Liver Disease (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118594
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate 632-93-9 99.79%
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC).
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • HY-D3000
    NIR-RED ROS-H2O2 Probe
    NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).
    NIR-RED ROS-H2O2 Probe
  • HY-118594R
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard) 632-93-9
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard) is the analytical standard of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HY-118594). This product is intended for research and analytical applications. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC).
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard)