1. Disease Areas
  2. Cancer Urogenital Disease
  3. Urogenital Cancer
  4. Bladder Cancer

Bladder Cancer

Bladder cancer is a common malignancy originating in the urinary bladder's lining, with high incidence rates in regions such as Australia, New Zealand, and Europe, significantly influenced by smoking. It is categorized into non-muscle invasive (superficial) and muscle-invasive types, depending on tumor depth. The most prevalent form is transitional cell carcinoma, with squamous cell carcinoma and adenocarcinoma also occurring, particularly in areas affected by schistosomiasis. Key risk factors include smoking, chemical exposure, family history, age, gender, and chronic bladder inflammation. Clinical manifestations often involve hematuria, dysuria, urinary frequency, urgency, and abdominal or back pain. If untreated, the disease may metastasize to lymph nodes, bones, lungs, or liver. Treatment strategies encompass surgery, chemotherapy, radiation therapy, and immunotherapy, with early detection playing a crucial role in improving outcomes. Specialized nursing care in urology and oncology is essential for managing this condition effectively.

Bladder Cancer (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122888
    MPT0L145 2070837-24-8
    MPT0L145 is a PIK3C3/FGFR inhibitor, with a Kd value of 0.53 nM for PIK3C3. MPT0L145 decreases the phosphorylation of FGFR1, FGFR3 and their downstream proteins (FRS2, ERK and Akt). MPT0L145 induces G0/G1 cell cycle arrest and decreased protein levels of cyclin E. MPT0L145 promotes mitochondrial dysfunction, ROS production, and DNA damage. MPT0L145 is an autophagy inhibitor. MPT0L145 significantly sensitizes cancer cells to targeted or chemotherapeutic agents. MPT0L145 can be used for cancer research, such as bladder cancer and NSCLC.
    MPT0L145