2. Disease Areas
  3. Neurological, Eye or Ear Disease
  4. Anxiety or Fear-Related Disease

Anxiety or Fear-Related Disease

Anxiety or fear-related disorders encompass conditions such as generalized anxiety disorder and separation anxiety disorder, characterized by symptoms including nervousness, agitation, and a persistent sense of tension. The SLC6A4 gene is a key genetic factor associated with these disorders, involved in serotonin transport and linked to pathways like Signal Transduction and Class A/1 (Rhodopsin-like receptors). Pharmacological agents such as Amantadine and Amlodipine have been implicated in the treatment or management of anxiety symptoms. Affected tissues include the brain and breast, with related phenotypes involving the nervous system and normal physiological function. Phobic Disorder, also known as phobic anxiety disorder, encompasses conditions such as agoraphobia and specific phobias, characterized by excessive and persistent fear of specific situations or objects. The MAOA gene is significantly associated with this disorder, which is involved in pathways including Signal Transduction and GPCR downstream signaling. Treatment options include the medications Paroxetine and Venlafaxine. The amygdala and eye are key affected tissues, with related phenotypes involving the nervous system and homeostasis/metabolism.

Anxiety or Fear-Related Disease (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-165624A
    (S)-LY-41 136296-40-7
    (S)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease, such as depression and anxiety.
    (S)-LY-41
  • HY-165624B
    (R)-LY-41 136296-43-0
    (R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety.
    (R)-LY-41
  • HY-167238
    RS-30199 123882-60-0
    RS-30199 is an anxiogenic agent. RS-30199 interacts with the 5-HT1A receptor. RS-30199 prolongs intromission latency. RS-30199 fully inhibits the facilitation of sexual behaviour caused by Delequamine (HY-106874).
    RS-30199