1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Cyclooctyne-O-amido-PEG3-PFP ester

Cyclooctyne-O-amido-PEG3-PFP ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Cyclooctyne-O-amido-PEG3-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Cyclooctyne-O-amido-PEG3-PFP ester Chemical Structure

Cyclooctyne-O-amido-PEG3-PFP ester Chemical Structure

CAS No. : 2101206-33-9

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Description

Cyclooctyne-O-amido-PEG3-PFP ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-amido-PEG3-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

551.50

Formula

C25H30F5NO7

CAS No.
SMILES

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCNC(COC2C#CCCCCC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Cyclooctyne-O-amido-PEG3-PFP ester Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cyclooctyne-O-amido-PEG3-PFP ester
Cat. No.:
HY-133575
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