2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. CL-283796

CL-283796 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research.

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CL-283796

CL-283796 Chemical Structure

CAS No. : 107376-72-7

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CL-283796 Related Antibodies

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Description

CL-283796 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research[1].

IC50 & Target[1]

ACAT

 

In Vivo

CL-283796 (p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks) reduces LDL cholesterol without affecting cholesterol absorption in African green monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult African green monkeys fed an atherogenic diet for approximately 6 weeks[1]
Dosage: 10 and 30 mg/kg
Administration: p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks
Result: Resulted in a 24.1% reduction in total plasma cholesterol after 30 days (10 mg/kg dose).
Resulted in significant reductions in LDL cholesterol but non-significant effects on VLDL cholesterol values.
Showed no significant effects on plasma triglyceride values, HDL cholesterol, and apolipoproteins A-I, B and E levels.
Decreased the total plasma cholesterol (TPC)/HDL cholesterol ratios by 40% after 10 weeks.
Showed no significant effect on cholesterol absorption.
Did not affect body weights.
Molecular Weight

457.09

Formula

C28H41ClN2O
CAS No.
SMILES

O=C(NC1=C(C)C=C(Cl)C=C1C)N(CCCCCCC)CC2=CC=C(CCC(C)C)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CL-283796 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL-283796107376-72-7CL283796CL 283796AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseacyltransferaseLDL cholesterolcholesterol absorptionhypercholesterolemiaInhibitorinhibitorinhibit

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