CL 277082 

CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor^[1].

CL 277082 inhibits ACAT in cultured smooth muscle cells (IC₅₀ = 0.8 μM). CL 277082 does not inhibit fatty acid incorporation into triglycerides or phospholipids. CL 277082 does not inhibit other cholesterol esterifying enzymes such as lecithin:cholesterol acyltransferase (LCAT) and pancreatic cholesterol esterase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CL 277082 is a potent inhibitor of cholesterol absorption in cholesterol-fed rats by markedly inhibiting increases in liver and serum cholesterol concentration (ED₅₀ = 5.2 mg/kg per day) while increasing the excretion of neutral ¹⁴C-labeled sterol in the feces^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

430.57

C₂₆H₃₆F₂N₂O

96224-26-9

O=C(NC1=CC=C(F)C=C1F)N(CC2=CC=C(CC(C)(C)C)C=C2)CCCCCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Largis EE, et al. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90.  [Content Brief]