2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. CK-2289

CK-2289 is an inhibitor of type III cyclic 3'5'-adenosine monophosphate phosphodiesterase (PDE). CK-2289 can inhibit platelet aggregation and decreases mean arterial blood pressure. CK-2289 can be used for the research of cardiovascular disease, such as congestive heart failure.

For research use only. We do not sell to patients.

CK-2289

CK-2289 Chemical Structure

CAS No. : 101183-99-7

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CK-2289 Related Antibodies

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Description

CK-2289 is an inhibitor of type III cyclic 3'5'-adenosine monophosphate phosphodiesterase (PDE). CK-2289 can inhibit platelet aggregation and decreases mean arterial blood pressure. CK-2289 can be used for the research of cardiovascular disease, such as congestive heart failure[1].

IC50 & Target[1]

PDE Ⅲ

 

In Vitro

CK-2289 (1-100 μM) inhibits human platelet aggregation produced by adenosine diphosphate and sodium arachidonate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CK-2289 Related Antibodies
In Vivo

CK-2289 (0.03-1 mg/kg, i.v.) increases myocardial dP/dTmax and decreases mean arterial blood pressure in dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

282.30

Formula

C15H14N4O2
CAS No.
SMILES

O=C1NC(C(C2=CC=C(N3C=NC=C3)C=C2)=O)=C(CC)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK-2289 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK-2289101183-99-7CK2289CK 2289Phosphodiesterase (PDE)congestive heart failurePDEphosphodiesteraseblood pressureplatelet aggregationInhibitorinhibitorinhibit

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