2. Others Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Drug Derivative Apoptosis Caspase PARP
  4. CHNQD-00824

CHNQD-00824 is a Terphenyllin (HY-119821) derivative with potent anticancer effect. CHNQD-00824 inhibits the proliferation and migration of cancer cells via DNA damage. CHNQD-00824 triggers apoptosis and inhibits Doxycin Hydrochloride (DOX)-induced liver-specific enlargement in zebrafish embryos. CHNQD-00824 can be used for cancer research, such as liver and breast cancer.

For research use only. We do not sell to patients.

CHNQD-00824

CHNQD-00824 Chemical Structure

CAS No. : 2222643-74-3

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CHNQD-00824 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

CHNQD-00824 is a Terphenyllin (HY-119821) derivative with potent anticancer effect. CHNQD-00824 inhibits the proliferation and migration of cancer cells via DNA damage. CHNQD-00824 triggers apoptosis and inhibits Doxycin Hydrochloride (DOX)-induced liver-specific enlargement in zebrafish embryos. CHNQD-00824 can be used for cancer research, such as liver and breast cancer[1].

In Vitro

CHNQD-00824 (72 h) exhibits potent inhibitory activity against a panel of cancer cells, including RCC4, HeLa, Hep G2, U2OS, U251, DU145, TE-1, BT549, HCT8, and MCF7 cells, with IC50 values of 2.65, 0.45, 7.64, 0.44, 5.43, 0.91, 4.35, 0.16, 0.61, and 3.66 μM[1].
CHNQD-00824 (0-8 μM, 7-13 days) dose-dependently inhibits colony formation in BT549 cells[1].
CHNQD-00824 (0-10 μM, 0-24 h) inhibits cell migration of BT549 cells in a time- and concentration dependent manner[1].
CHNQD-00824 (0-8 μM, 24 h) induces G2 phase cell cycle arrest, and induces apoptosis via DNA damage in a concentration- and caspase-dependent manner in BT549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHNQD-00824 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.25, 0.5, and 1 μM
Incubation Time: 24 h
Result: Decreased percentage of cells in the G2 phase in a dose-dependent manner from 31.78% to 10.44%.

Cell Migration Assay [1]

Cell Line: BT549 cells
Concentration: 0, 1, 5, and 10 μM
Incubation Time: 0, 12, and 24 h
Result: Showed no significant effect on the cell viability after 12 h treatment.
Significantly inhibited cell migration at concentrations of 5 and 10 μM.
Exhibited a notable inhibitory effect on cell migration after 24 h at concentrations of 1, 5, and 10 μM.

Cell Proliferation Assay[1]

Cell Line: BT549 cells
Concentration: 0, 2, 4, 5, and 8 μM
Incubation Time: 7, and 13 days
Result: Dose-dependently reduced the formation of colonies after 13 days.
Almost completely inhibited cell proliferation at a concentration of 5 μM after 7 days.

Apoptosis Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.25, 0.5, and 1 μM
Incubation Time: 0, 12, and 24 h
Result: Resulted in a dose-dependent increase in the percentage of apoptotic cells (0.25, 0.5, and 1 μM), reaching 10.66%, 14.67%, and 23.50%, respectively.
Significantly induced apoptosis in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: BT549 cells
Concentration: 0, 0.5, 2, and 8 μM
Incubation Time: 24 h
Result: Led to an increase in the levels of cleaved-PARP1 (C-PARP1) and Cytochrome C (Cyto C) at 0.5, 2, and 8 μM.
Increased the level of cleaved-caspase 3 (C-Cas3) at the concentrations of 2 and 8 μM.
Increased the pre-apoptotic protein BAD at the concentrations of 8 μM.
Increased γH2AX levels in a concentration-dependent manner.
In Vivo

CHNQD-00824 (0-15 μM, from 24 to 48 h post-fertilization) causes cell death via DNA damage in Zebrafish[1].
CHNQD-00824 (1.25-5 μM, from day 3 to day 7 post-fertilization) inhibits DOX-induced liver-specific enlargement in zebrafish embryos in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

418.48

Formula

C26H26O5
CAS No.
SMILES

OC1=CC=C(C2=C(C=C(C3=CC=C(C=C3)OCC=C)C(OC)=C2OCC=C)OC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHNQD-00824 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-008242222643-74-3CHNQD00824CHNQD 00824Drug DerivativeApoptosisCaspasePARPDrug derivativepoly ADP ribose polymeraseTerphenyllinDNA damageliver-specific enlargementzebrafish embryosliver cancerbreast cancerBT549 cellsInhibitorinhibitorinhibit

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