2. Stem Cell/Wnt
  3. Hedgehog
  4. CBR-096-4

CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis.

For research use only. We do not sell to patients.

CBR-096-4

CBR-096-4 Chemical Structure

CAS No. : 1776931-05-5

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CBR-096-4 Related Antibodies

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Description

CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis[1].

Molecular Weight

636.74

Formula

C35H40N8O4
CAS No.
SMILES

O=C1N(C(C)CC)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@](C6=CC=CC=C6)(CN7N=CC=N7)OC5)C=C4)CC3)C=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CBR-096-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBR-096-41776931-05-5Hedgehogliver fibrosisantifibroticMFBInhibitorinhibitorinhibit

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HY-117485
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