2. Neuronal Signaling MAPK/ERK Pathway Apoptosis
  3. Sigma Receptor p38 MAPK Apoptosis
  4. BS148

BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma.

For research use only. We do not sell to patients.

BS148

BS148 Chemical Structure

CAS No. : 2162116-09-6

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BS148 Related Antibodies

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Sigma 1 Receptor Sigma 2 Receptor

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma[1][2].

IC50 & Target[1][2]

Sigma 2 Receptor

20 nM (Ki)

Sigma 1 Receptor

540 nM (Ki)

Molecular Weight

361.61

Formula

C21H31NS2
CAS No.
SMILES

N1(CC2SC3(CCCCC3)SC2)CCC(CC4=CC=CC=C4)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BS148 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BS1482162116-09-6BS 148BS-148Sigma Receptorp38 MAPKApoptosissigma-2 receptor agonistPERKATF4CHOPMAPKmelanomaInhibitorinhibitorinhibit

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