2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. FLAP Endogenous Metabolite
  4. BRP-7

BRP-7 is a 5-lipoxygenase activating protein (FLAP) inhibitor. BRP-7 inhibits the co-localization of 5-lipoxygenase (5-LOX) and FLAP by targeting FLAP, thereby blocking the transfer of arachidonic acid (AA) to 5-LOX and suppressing the production of leukotrienes (LTs) (IC₅₀ = 0.15 μM). BRP-7 does not inhibit cyclooxygenase (COX-1/COX-2) or microsomal prostaglandin E₂ synthase-1 (mPGES-1), and does not affect cell viability or AA release. BRP-7 exhibits significant anti-inflammatory effects in rat pleurisy and mouse peritonitis models. BRP-7 can be used for the study of inflammatory diseases.

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BRP-7

BRP-7 Chemical Structure

CAS No. : 612046-20-5

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BRP-7 Related Antibodies

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Description

BRP-7 is a 5-lipoxygenase activating protein (FLAP) inhibitor. BRP-7 inhibits the co-localization of 5-lipoxygenase (5-LOX) and FLAP by targeting FLAP, thereby blocking the transfer of arachidonic acid (AA) to 5-LOX and suppressing the production of leukotrienes (LTs) (IC₅₀ = 0.15 μM). BRP-7 does not inhibit cyclooxygenase (COX-1/COX-2) or microsomal prostaglandin E₂ synthase-1 (mPGES-1), and does not affect cell viability or AA release. BRP-7 exhibits significant anti-inflammatory effects in rat pleurisy and mouse peritonitis models. BRP-7 can be used for the study of inflammatory diseases[1][2].
Molecular Weight

402.96

Formula

C26H27ClN2
CAS No.
SMILES

ClC1=C(CN2C3=C(N=C2C(C)C4=CC=C(CC(C)C)C=C4)C=CC=C3)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRP-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRP-7612046-20-5BRP7BRP 7FLAPEndogenous Metabolite5-lipoxygenase-activating protein5-LO activating protein5-lipoxygenase5-lipoxygenase activating proteinleukotrienebenzimidazoleinflammationInhibitorinhibitorinhibit

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