2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. BRL-41992

BRL-41992 is a selective α₂B-adrenergic receptor antagonist. BRL-41992 exhibits 94-fold higher selectivity for the α₂B-receptor than for the α₂A-receptor with Kᵢ values in neonatal rat lung tissue (expressing the α₂B-receptor) and in human platelet membranes (expressing the α₂A-receptor) of 1.1 and 103.3 nM. BRL-41992 can be used to verify the functional differences of α₂ receptor subtypes.

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BRL-41992

BRL-41992 Chemical Structure

CAS No. : 124097-52-5

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BRL-41992 Related Antibodies

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Description

BRL-41992 is a selective α₂B-adrenergic receptor antagonist. BRL-41992 exhibits 94-fold higher selectivity for the α₂B-receptor than for the α₂A-receptor with Kᵢ values in neonatal rat lung tissue (expressing the α₂B-receptor) and in human platelet membranes (expressing the α₂A-receptor) of 1.1 and 103.3 nM. BRL-41992 can be used to verify the functional differences of α₂ receptor subtypes[1][2].
IC50 & Target[1]

Alpha-2A adrenergic receptor

1.1 nM (Ki)

Alpha-2B adrenergic receptor

103.3 nM (Ki)

Molecular Weight

264.36

Formula

C18H20N2
CAS No.
SMILES

CN(CN1[C@]2(C3=CC=CC=C3CC4=CC=CC=C41)[H])[C@@H]2C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRL-41992 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL-41992124097-52-5BRL41992BRL 41992Adrenergic ReceptorBeta Receptorα?-adrenoceptor subtypesAntinociceptionSelective antagonistsPharmacological heterogeneityInhibitorinhibitorinhibit

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