BL-1005 (Synonyms: BS2463)

Cat. No.: HY-179116: Data Sheet Handling Instructions
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BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC₅₀ of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC₅₀ >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection.

For research use only. We do not sell to patients.

BL-1005 Chemical Structure

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References
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Description

In Vitro

BL-1005 (0.02-50 μM; 48 h) reduces cell viability in HEK293, HeLa and HepG2 cells with a CC₅₀ of 37.3, 21.3 and 22.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BL-1005 (0.6-1.2 μM; 2 h) induces a sustained paralysis in both adult and juvenile S. mansoni^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Schistosoma mansoni (adult and juvenile, 28-42-day-old)^[1]
Dosage:	0.6 μM, 1.2 μM
Administration:	2 h
Result:	Induced a sustained paralysis in both adult and juvenile S. mansoni, with partial recovery of motility over 9 days.

Molecular Weight

422.88

Formula

C₁₉H₁₇ClF₂N₄OS

SMILES

FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Francisco KR, et al. Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.681061. [Content Brief]

BL-1005 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BL-1005BS2463BL1005BL 1005BS 2463BS-2463ParasiteSchistosoma mansoni,HEK293,HeLa,HepG2
Inhibitorinhibitorinhibit

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