2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism Phosphodiesterase (PDE)
  4. BJH-86

BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer.

For research use only. We do not sell to patients.

BJH-86

BJH-86 Chemical Structure

CAS No. : 3067849-10-6

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BJH-86 Related Antibodies

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Description

BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer[1].

IC50 & Target[1]

PDE10A

 

In Vitro

BJH-86 (1-10 μM, 30 min-96 h) potently inhibits mitochondrial complex I (oxygen consumption rate inhibition IC50 = 5 μM) in A549 human lung cancer cells and EO771 murine breast cancer cells[1].
BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A, IC50 >10 μM) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BJH-86 Related Antibodies
In Vivo

BJH-86 (2-30 mg/kg, i.v.) inhibits tumor growth in C57Bl6 mice bearing EO771 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6 mice bearing EO771 xenografts[1]
Dosage: 2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
Administration: Intravenously injection
Result: Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.
Molecular Weight

371.43

Formula

C23H21N3O2
CAS No.
SMILES

COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BJH-86 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BJH-863067849-10-6BJH86BJH 86Mitochondrial MetabolismPhosphodiesterase (PDE)mitochondrial complex 1PDE10Aoxygen consumptioncancerA549breast cancerInhibitorinhibitorinhibit

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