2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. BJH-60

BJH-60 is a mitochondrial complex 1 inhibitor. BJH-60 can inhibit mitochondrial oxygen consumption rate with an IC50 of 1.9 μM in A549 cells. BJH-60 shows no PDE inhibitory effect. BJH-60 can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

BJH-60

BJH-60 Chemical Structure

CAS No. : 3067849-06-0

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BJH-60 Related Antibodies

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Description

BJH-60 is a mitochondrial complex 1 inhibitor. BJH-60 can inhibit mitochondrial oxygen consumption rate with an IC50 of 1.9 μM in A549 cells. BJH-60 shows no PDE inhibitory effect. BJH-60 can be used for the research of cancer, such as breast cancer[1].

In Vitro

BJH-60 (3-100 μM, 96 h) inhibits cell proliferation in A549 and EO771 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BJH-60 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A549 and EO771 cells
Concentration: 3, 10 and 100 μM
Incubation Time: 96 h
Result: Significantly reduced cell numbers at 100 μM.
In Vivo

BJH-60 (disodium phosphate produrg) (2 mg/kg; IV; 1 hour before XRT) radiosensitizes EO771 mammary gland tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6 bearing EO771 mammary gland tumors[1]
Dosage: 2 mg/kg
Administration: IV; 1 hour before XRT
Result: Doubled the tumor growth delay to 4 days.
Molecular Weight

355.43

Formula

C24H21NO2
CAS No.
SMILES

OCC1=CC=C(C2=CC=CC(CC3=CC=NC4=CC=C(OC)C=C34)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BJH-60 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BJH-603067849-06-0BJH60BJH 60Mitochondrial Metabolismmitochondrial complexoxygen consumptionA549PDEEO771breast cancerInhibitorinhibitorinhibit

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