2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs FAK
  4. BI-0319

BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer. (Structure Note: Pink: PTK2/FAK ligand (HY-43760); Blue: VHL ligand (HY-125845); Black: linker (HY-140189); VHL ligand-Linker: (HY-103602A))

For research use only. We do not sell to patients.

The BI-0319 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.

BI-0319

BI-0319 Chemical Structure

CAS No. : 2341740-85-8

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BI-0319 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer[1][2]. (Structure Note: Pink: PTK2/FAK ligand (HY-43760); Blue: VHL ligand (HY-125845); Black: linker (HY-140189); VHL ligand-Linker: (HY-103602A))

Molecular Weight

1061.13

Formula

C52H59F3N8O11S
CAS No.
SMILES

O=C1CCC2=CC=CC(OC3=NC(NC4=C(C=C(C=C4)C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)OC)=NC=C3C(F)(F)F)=C21
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BI-0319 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-03192341740-85-8BI0319BI 0319PROTACsFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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