2. Immunology/Inflammation
  3. Nectin-4
  4. BGC1614

BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an KD of 3.859 × 10-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer).

For research use only. We do not sell to patients.

BGC1614

BGC1614 Chemical Structure

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Description

BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an KD of 3.859 × 10-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer)[1].

In Vivo

BGC1614 (1.0-3.0 mg/kg, i.v., once a week, 21 days) exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 or N87 cells were implanted into nude mice[1]
Dosage: 1.0, 3.0 mg/kg
Administration: i.v., once a week, 21 days
Result: Achieved tumor growth inhibition (TGI) rates of 96.3% in nude mice bearing PC-3 tumor xenografts.
Achieved tumor growth inhibition (TGI) rates of 41.9% and 70.1% respectively in nude mice bearing N87 tumor xenografts.
Showed no significant changes in body weight.
Molecular Weight

8375.70

Formula

C382H578N94O104S7
SMILES

NC([C@@H]([C@H]([C@@H]1CCCN1C(C[C@H](C(N(C([C@H](C(C)C)NC([C@@H](N(C(OCC2=CC=C(C=C2)NC([C@@H](NC([C@H](C(C)C)NC(CCCC(N[C@H](C(NCCCC[C@@H](C(N)=O)NC(COCCOCCOCCOCCOCCOCCNC(CN(C)C(CN(C)C(CN(C)CC(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C(CN(C)C([C@H](C)NC([C@@H]3CSCCC(N4CN(CN5C4)C(CCSCCC(N6CCC[C@H]6C(N[C@@H](CC7=C8C=CC=CC8=CC=C7)C(NC(CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N9CCC[C@H]9C(N%10C[C@H](O)C[C@H]%10C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N3)=O)=O)=O)=O)=O)CO)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)CC(O)=O)=O)CCCCNC(N)=N)=O)CCSC)=O)CSCCC5=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN%15N=NC%16=C%15C(C=CC=C%17)=C%17CN(C(CCC(NCCOCCOCCOCCOCCOCCOCC(NCCC(N(CC(N(CC(N(CC(N(CC(N(CC(N(CC(N(CC(N(CC(N(CC(N(CC(N[C@H](C(N[C@H](C(C[C@@H](CC(O)=O)C(N[C@@H]%18C(N%19C[C@H](O)C[C@H]%19C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N%20CCC[C@H]%20C(N[C@H](C(NC%21CSCCC(N%22CN(CN(C(CCSCCNC([C@@H](NC([C@H](NC([C@H](NC([C@@H]%23CCCN%23C([C@@H](NC([C@@H](NC%21=O)CC(C)C)=O)CC%24=CNC=N%24)=O)=O)C(O)=O)=O)CC%25=CNC%26=CC=CC=C%25%26)=O)CCCCNC(N)=N)=O)=O)C%22)C(CCSC%18)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CCCCNC(N)=N)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)=O)=O)=O)C%27=C%16C=CC=C%27)=O)=O)=O)CCCNC(N)=O)=O)=O)C)C(C)C)=O)=O)C)[C@H](CC)C)OC)=O)OC)C)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
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BGC1614 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BGC1614BGC 1614BGC-1614Nectin-4PDCsPC-3N87prostate cancergastric cancerInhibitorinhibitorinhibit

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