Bay-X-7195 

Bay-X-7195 is a CYS leukotriene 1 receptor (CYS LT1) antagonist. Bay-X-7195 shows an antagonistic action to LTD4-induced bronchoconstriction in vitro and in vivo. Bay-X-7195 can be used foe the study of allergic and asthmatic^[1][2].

In in vitro experiments, Bay-X-7195 inhibits LTD4-induced contraction of isolated guinea pig tracheal muscle (pA₂ = 8.03)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bay-X-7195 at doses of 3-30 mg/kg clearly inhibits LTD4-induced increases in respiratory resistance (Rrs) in guinea pigs^[2].
In mice, aeroantigen-induced airway inflammation are clearly inhibited by Bay-X-7195^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

520.64

C₃₀H₃₂O₆S

143538-27-6

O=C(O)C1=CC=C(S[C@@H](CCC(O)=O)/C=C\CC2=CC=C(OCCCCOC3=CC=CC=C3)C=C2)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Boulet LP, et al. Inhibitory effects of BAY x 7195, a CYS leukotriene 1 receptor antagonist, on allergen-induced asthmatic responses. Ann Allergy Asthma Immunol. 1997 Aug;79(2):155-61.  [Content Brief]

  [2]. Tanaka H, et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. Prostaglandins. 1995 Nov-Dec;50(5-6):269-85.  [Content Brief]